General Information

  • ID:  hor004134
  • Uniprot ID:  Q99P85
  • Protein name:  Resistin-like alpha
  • Gene name:  Retnla
  • Organism:  Rattus norvegicus (Rat)
  • Family:  Resistin/FIZZ family
  • Source:  Animal
  • Expression:  Highest levels in adipose tissue.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Rattus (genus), Murinae (subfamily), Muridae (family), Muroidea, Myomorpha (suborder), Rodentia (order), Glires, Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence Information

  • Sequence:  DGTLDIIGKKKVKELLAHQDNYPSAVRKTLSCTNVKSMSKWASCPAGMTATGCSCGFACGSWEIQNENICNCLCLIVDWAYARCCQLS
  • Length:  88(24-111)
  • Propeptide:  MKTATCSLLICVFLLQLMVPVNTDGTLDIIGKKKVKELLAHQDNYPSAVRKTLSCTNVKSMSKWASCPAGMTATGCSCGFACGSWEIQNENICNCLCLIVDWAYARCCQLS
  • Signal peptide:  MKTATCSLLICVFLLQLMVPVNT
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Plays a role in pulmonary vascular remodeling
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:   NA
  • IC50:  NA
  • EC50:  NA
  • ED50:  NA
  • Kd:  NA
  • Half life:  NA

Structure

  • Disulfide bond:  32-85; 44-84; 53-70; 55-72; 59-74
  • Structure ID:  AF-Q99P85-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004134_AF2.pdbhor004134_ESM.pdb

Physical Information

Mass: 1110713 Formula: C408H652N114O126S12
Absent amino acids: Common amino acids: C
pI: 7.86 Basic residues: 10
Polar residues: 36 Hydrophobic residues: 28
Hydrophobicity: -1.02 Boman Index: -9602
Half-Life / Aliphatic Index: 1.1 hour Aliphatic Index: 75.45
Instability Index: 4431.14 Extinction Coefficient cystines: 20105
Absorbance 280nm: 231.09

Literature

  • PubMed ID:  NA
  • Title:  NA